ADT-OH
CAS No. : 18274-81-2
(Synonyms: 5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione; ACS 1)
| Size | Price | Stock |
|---|---|---|
| 100mg | $46 | In-stock |
| 250mg | $77 | In-stock |
| 1g | $197 | In-stock |
| 5g | $599 | In-stock |
| 10g | $880 | In-stock |
| 25g | $1809 | In-stock |
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| 100 g | Get quote | |
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| Cat. No. : | HY-109582 |
| M.Wt: | 226.35 |
| Formula: | C9H6OS3 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
ADT-OH is a hydrogen sulfide-releasing donor. ADT-OH induces apoptosis and upregulates FADD. ADT-OH inhibits FAK/Paxillin. ADT-OH has the potential for the research of cancer diseases[1][5].
In Vitro:ADT-OH (0-200 μM, 24-48 h) significantly inhibits metastasis of TNBC cells (MDA-MB-231 and 4T1-Luci) in the absence of proliferation inhibition[2].
ADT-OH (7.5-120 μM, 48 h) synergistically enhances the antitumor activity of celecoxib in human colorectal cancer cells HCT116[3].
ADT-OH promotes self-renewal and antiapoptosis ability of cultured NPCs[4].
ADT-OH exhibits anti-metastatic activity on malignant melanoma cells through inhibition of FAK/Paxillin signaling pathways[5].
In Vivo:ADT-OH (10-30 mg/kg, i.p., every day) reveals a potent anti-metastatic activity in three different mice models, the MDA-MB-231 orthotopic xenograft model, the 4T1-Luci orthotopic model and the 4T1-Luci tail vein metastasis model[2].
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