LY334370
CAS No. : 182563-08-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $120 | In-stock |
| 25mg | $270 | In-stock |
| 50mg | $400 | In-stock |
| 100mg | $580 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103107 |
| M.Wt: | 351.42 |
| Formula: | C21H22FN3O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 55.5 mg/mL |
LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM. IC50 & Target: Ki: 1.6 nM (5-HT1F) In Vitro: LY334370 has no vasoconstrictor effects on human cerebral arteries in vitro until a dose of 10-5 M, at which it produces a contraction of 8.5±5.7%; however, this is not significant[1]. In Vivo: Following intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se, since the actual dural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg)[1].
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