AZ9482
CAS No. : 1825345-33-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $66 | In-stock |
| 5mg | $176 | In-stock |
| 10mg | $286 | In-stock |
| 25mg | $550 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-119653 |
| M.Wt: | 450.49 |
| Formula: | C26H22N6O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
AZ9482 is a triple PARP1/2/6 inhibitor, with IC50 values of 1 nM, 1 nM and 640 nM for PARP1, PARP2 and PARP6, respectively[1].
In Vitro: AZ9482 exhibits an EC50 of 24 nM in MDA-MB-468 cells[1].
AZ0108 treatment prevents CHK1 MARylation and induces hyperphosphorylation of CHK1, contributing to MPS formation and dysregulation of the cell cycle[1].
In Vivo: AZ0108 also displays toxicity in vivo, the molecular basis of which is currently undefined, limiting pharmacological evaluation of AZ0108[1].
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