Size | Price | Stock |
---|---|---|
1mg | $500 | In-stock |
5 mg | Get quote | |
10 mg | Get quote | |
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Cat. No. : | HY-100219 |
M.Wt: | 446.66 |
Formula: | C28H46O4 |
Purity: | >98 % |
Solubility: | DMSO : 100 mg/mL (223.88 mM; Need ultrasonic) |
CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM[1]. IC50 & Target: IC50: 0.82 nM[1] In Vitro: CB1151 (0-100 nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [3H]-thymidine incorporation, exhibits an IC50 value of 0.82 nM[1]. CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC50 of 1.2 nM, the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC50=3.2nM) in MCF-7 cells transfected with the CAT reporter[1]. CB1151 shows a functional dissociation constant (Kdf) value of 3.6 nM. The ligand concentration that provides 50% of protease-resistant VDR fragment is defined by Kdf, this is different from that of the traditional dissociation constant (Kd)[2].
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