CB1151


CAS No. : 182369-28-4

182369-28-4
Price and Availability of CAS No. : 182369-28-4
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Cat. No. : HY-100219
M.Wt: 446.66
Formula: C28H46O4
Purity: >98 %
Solubility: DMSO : 100 mg/mL (223.88 mM; Need ultrasonic)
Introduction of 182369-28-4 :

CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM[1]. IC50 & Target: IC50: 0.82 nM[1] In Vitro: CB1151 (0-100 nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [3H]-thymidine incorporation, exhibits an IC50 value of 0.82 nM[1].
CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element with a EC50 of 1.2 nM, the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC50=3.2nM) in MCF-7 cells transfected with the CAT reporter[1].
CB1151 shows a functional dissociation constant (Kdf) value of 3.6 nM. The ligand concentration that provides 50% of protease-resistant VDR fragment is defined by Kdf, this is different from that of the traditional dissociation constant (Kd)[2].

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