BMS-195614
CAS No. : 182135-66-6
(Synonyms: BMS 614)
| Size | Price | Stock |
|---|---|---|
| 1mg | $45 | In-stock |
| 5mg | $185 | In-stock |
| 10mg | $295 | In-stock |
| 25mg | $590 | In-stock |
| 50mg | $950 | In-stock |
| 100mg | $1520 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-101259 |
| M.Wt: | 448.51 |
| Formula: | C29H24N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 30 mg/mL (ultrasonic;warming) |
BMS-195614 (BMS 614) is an orally active neutral RARα-selective antagonist with a Ki of 2.5 nM. BMS-195614 restores the expression of Bcl2. BMS-195614 inhibits the transactivation of NF-κB, AP-1 and PPAR. BMS-195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis[1][2][3][4][5].
In Vitro:BMS-195614 (10-20 μM) reduces blue light-induced phototoxicity and modulates inflammation and angiogenesis in the presence of A2E in RPE cells[2].
BMS-195614 (6 μM, 24 h) reverses the anti-inflammatory effect of Vitamin A (HY-B1342) and RA on the release of IL-6 by LPS-activated BV-2 cells[3].
BMS-195614 (1 μM, 24 h) inhibits Retinoic acid (HY-14649)induced migration of MC3T3E1 osteoblastlike cells[4].
In Vivo:BMS-195614 (2-10 mg/kg, p.o., 7 days) results in minimal or no inhibition of overall spermatogenesis in mice[5].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- BMS-195614
- Cat. No.:
- HY-101259
- Quantity:
Your information is safe with us.