Arzoxifene
CAS No. : 182133-25-1
(Synonyms: LY353381; SERM III)
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| Cat. No. : | HY-13556 |
| M.Wt: | 475.60 |
| Formula: | C28H29NO4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Arzoxifene (LY353381) is an orally active selective estrogen receptor modulator with a fixed ring structure similar to raloxifene. Arzoxifene has minimal side effects with powerful antiestrogenic effects on breast cancer and endometrium, with equally strong favorable estrogenic effects on bone and lipid profile[1]. IC50 & Target: estrogen[1] In Vitro: Arzoxifene reduces estrogen receptor expression in endometrial cancer cell lines (ECC-1)[1]. In Vivo: Arzoxifene inhibits MCF-7 breast cancer xenograft growth in oophorectomized athymic mice. Arzoxifene is reported to prevent body weight increase in oophorectomized rats[1].
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