DMU2139
CAS No. : 1821143-80-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $145 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $465 | In-stock |
| 100mg | $750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101285 |
| M.Wt: | 289.33 |
| Formula: | C19H15NO2 |
| Purity: | >98 % |
| Solubility: | Ethanol : 5 mg/mL (ultrasonic);DMSO : 77.5 mg/mL (ultrasonic) |
DMU2139 is a potent and specific CYP1B1 inhibitor, with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively. IC50 & Target: IC50: 9 nM (CYP1B1), 795 nM (CYP1A1)[1]. In Vitro: DMU2139 (6j) shows 88 and 133-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2139, the EC50 is reversed back to 8.3 μM from 61 μM (seen in CYP1B1-expressing cells without any inhibitor). The EC50 value, in the presence of DMU2139, resembles the EC50 of cisplatin, 8.7μM, in cells transfected with the empty plasmid which has no CYP1B1 gene and therefore cannot express CYP1B1 protein[1].
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