DMU2105
CAS No. : 1821143-79-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $175 | In-stock |
| 25mg | $265 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $650 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101284 |
| M.Wt: | 259.31 |
| Formula: | C18H13NO |
| Purity: | >98 % |
| Solubility: | DMSO : 33.33 mg/mL (ultrasonic;warming;heat to 60°C) |
DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10 nM and 742 nM for CYP1B1 and CYP1A1, respectively. IC50 & Target: IC50: 10 nM (CYP1B1), 742 nM (CYP1A1)[1]. In Vitro: DMU2105 (Compound 7k) shows 74 and 120-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2105 however, the EC50 goes down to 1 μM indicating that the cells have suffered from toxicity which may have been mediated by CYP1B1 inhibition. Un-transfected cells (HEK293: pcDNA3.1), when treated with cisplatin and DMU2105 (10×IC50) do not show any perceptible decrease of cisplatin EC50 (8.5 μM ± 0.9)[1].
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