TAK-071
CAS No. : 1820812-16-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $109 | In-stock |
| 10mg | $170 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-122190 |
| M.Wt: | 421.46 |
| Formula: | C24H24FN3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 135 mg/mL (ultrasonic) |
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM[1]. IC50 & Target: EC50: 520 nM (M1R)[1] In Vivo: TAK-071 increase hippocampal inositol monophosphate production through M1R activation and improved DB00747 -induced cognitive deficits in rats at 0.3 mg/kg[1].
TAK-071 also induce diarrhea at 10 mg/kg in rats[1].
Combining sub-effective doses of TAK-071 (3 mg/kg) with an acetylcholinesterase inhibitor significantly ameliorates DB00747-induced cognitive deficits in rats[1].
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