ZD8321
CAS No. : 182073-77-4
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| Cat. No. : | HY-U00256 |
| M.Wt: | 423.43 |
| Formula: | C18H28F3N3O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ZD8321 is a potent inhibitor of human Neutrophil elastase (NE) with a Ki of 13±1.7 nM. IC50 & Target: Ki: 13±1.7 nM (Neutrophil elastase)[1] In Vitro: TNFα-activated HUVEC is dose dependently inhibited by ZD8321.The adhesion between cancer cells with high elastase activity and TNFα-activated HUVEC is also inhibited by ZD8321. Expression of cell surface E-selectin by NE stimulation is suppressed in the presence of ZD8321. The concentration of soluble E-selectin in the medium increases after adhesive reaction between neutrophils and HUVEC. This increase is also dose dependently inhibited by ZD8321[2].
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