5-Chlorouracil
CAS No. : 1820-81-1
(Synonyms: Fluorouracil impurity)
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| Cat. No. : | HY-I0959 |
| M.Wt: | 146.53 |
| Formula: | C4H3ClN2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
5-Chlorouracil (Fluorouracil Impurity) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. In Vitro: 5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic. Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are incre ased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue. References
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