KC 12291 (hydrochloride)
CAS No. : 181936-98-1
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| Cat. No. : | HY-108502 |
| M.Wt: | 449.99 |
| Formula: | C22H28ClN3O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
KC 12291 hydrochloride is an orally active blocker of voltage-gated sodium channel (VGSC). KC 12291 hydrochloride reduces the amplitude of sustained Na+ current to exert antiischemic activity. KC 12291 hydrochloride has significant cardioprotective effect in vitro and in vivo[1].
In Vitro:KC 12291 hydrochloride (1 μM) reduces the peak of Na+ current approximately 60 % in rat ventricular cardiomyocytes[1] .
In Vivo:KC 12291 hydrochloride (0.63 mg/kg for p.o; once) exerts significant antiischemic activity in anesthetized rabbit model[1].
KC 12291 hydrochloride (60 mg/kg for p.o) has plasma Cmax values of 1.3 and 1.4 μg/mL for female and male rats, respectively, and the value of plasma Tmax is close to 2 h[1].
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