SPHINX31
CAS No. : 1818389-84-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $99 | In-stock |
| 10mg | $132 | In-stock |
| 50mg | $385 | In-stock |
| 100mg | $605 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117661 |
| M.Wt: | 507.51 |
| Formula: | C27H24F3N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 17.33 mg/mL (ultrasonic) |
SPHINX31 is a potent and selective SRPK1 inhibitor, with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 also decreases the mRNA expression of pro-angiogenic VEGF-A165a isoform. SPHINX31 can be used to research neovascular eye disease[1][2][3].
IC50 & Target: IC50: 5.9 nM (SRPK1)[1]
VEGF-A165a[2]
In Vitro: SPHINX31 (0.3-10 μM; 24 h) significantly down-regulates the expression of VEGF-A165a mRNA[2].
SPHINX31 (0.3 μM; 24 h) suppresses SRSF1 phosphorylation and nuclear localization[2].
SPHINX31 (0.3-10 μM; 24 h) decreases pre-tube formation and the rate of migration for human umbilical vein endothelial cells (HUVECs)[2].
In Vivo: SPHINX31 (200 μg/mL; twice daily topical eye drops) protects the retinal endothelial permeability barrier from diabetes-associated loss of integrity[3].
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