BMS-1166
CAS No. : 1818314-88-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $86 | In-stock |
| 5mg | $191 | In-stock |
| 10mg | $288 | In-stock |
| 25mg | $547 | In-stock |
| 50mg | $810 | In-stock |
| 100mg | $1200 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-102011 |
| M.Wt: | 641.11 |
| Formula: | C36H33ClN2O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
BMS-1166 is a potent PD-1/PD-L1 immune checkpoint inhibitor. BMS-1166 induces dimerization of PD-L1 and blocks its interaction with PD-1, with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation[1][2]. IC50 & Target: IC50: 1.4 nM (PD-1/PD-L1 interaction)[1]. In Vitro: BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1]. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1[2].
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