NTRC 0066-0
CAS No. : 1817791-73-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $180 | In-stock |
| 10mg | $290 | In-stock |
| 25mg | $580 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-100024 |
| M.Wt: | 565.71 |
| Formula: | C33H39N7O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20.83 mg/mL (36.82 mM; ultrasonic and warming and heat to 60°C) |
NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC50=0.9 nM). NTRC 0066-0 can be used for the research of cancer[1]. IC50 & Target: IC50: 0.9 nM (TTK)[1] In Vitro: NTRC 0066-0 has a low selectivity entropy and a relatively long target residence time on TTK and inhibits the proliferation of diverse cancer cell lines with a potency in the same range as that of classic chemotherapeutic agents such as doxorubicin. NTRC 0066-0, has subnanomolar potency in a TTK enzyme assay and inhibits the proliferation of cancer cell lines from diverse tumor tissue origin with IC50 from 11 to 290 nM at 5-day incubation time[1]. In Vivo: NTRC 0066-0 inhibited tumor growth in a mouse xenograft model of the human triple-negative breast cancer (TNBC) cell line MDA-MB-231[1].
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