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Cyclopiazonic acid


CAS No. : 18172-33-3

18172-33-3
Price and Availability of CAS No. : 18172-33-3
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Cat. No. : HY-N6771
M.Wt: 336.38
Formula: C20H20N2O3
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 18172-33-3 :

Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B[1][4][5].
In Vitro: Cyclopiazonic acid (10 μM) enhances 5-HT-induced contraction and reduces the antagonistic effect of 5-HT receptors in rat thoracic aorta [2].
Cyclopiazonic acid (10 μM, 48h) has an inhibitory effect on pacemaker current in sinoatrial node cells[3].
Cyclopiazonic acid (10 μM, 48h) exhibits antiviral activity against human respiratory syncytial virus by increasing intracellular calcium concentration in HEp-2 cells[4].
Cyclopiazonic acid (10 μM) inhibits the formation of certain metabolites of caffeine and testosterone and suppresses the biological activation of aflatoxin B through cytochrome P450 enzymes[5].
In Vivo: Cyclopiazonic acid (0.03, 0.06, 0.12 mg/kg; once a day; 28 days; i.p.) induces p53 dependent cell apoptosis and reproductive toxicity in mouse testes[1].

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