BAY-7598
CAS No. : 1816257-74-5
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| Cat. No. : | HY-120944 |
| M.Wt: | 505.56 |
| Formula: | C28H31N3O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BAY-7598, a chemical probe, is a potent, orally bioavailable, and selective MMP12 inhibitor with IC50s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively[1].
IC50 & Target:IC50: 0.085 nM (human MMP12), 0.67 nM (murine MMP12), 1.1 nM (rat MMP12)[1]
In Vitro:BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 with IC50s of 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM, respectively[1].
BAY-7598 inhibits murine MMP2, MMP3, MMP7, MMP8, and MMP9 with IC50s of 45, 270, 130, 54, and 210 nM, respectively[1].
BAY-7598 inhibits rat MMP2, MMP8, and MMP9 with IC50s of 45, 67, and 1000 nM, respectively[1].
In Vivo:BAY-7598 has moderate terminal elimination half-life (t1/2=4.6 h and 4.1 h for mouse (0.3 mg/kg, iv), mouse (5.0 mg/kg, p.o.) , respectively)[1].
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- Cat. No.:
- HY-120944
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