LEM-14
CAS No. : 1814881-70-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $480 | In-stock |
| 25mg | $790 | In-stock |
| 50mg | $1130 | In-stock |
| 100mg | $1520 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-114340 |
| M.Wt: | 478.56 |
| Formula: | C25H26N4O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
LEM-14 is a potent and selective NSD2 inhibitor with an IC50 of 132 µM. LEM-14 has very weak activitv
against NSD1 and has no activity against NSD3. LEM-14 inhibits fibrotic gene expression in ND but not DIO BMDMs. LEM-14 combined with ionizing radiation (IR) enhances the apoptosis rate and reduces the colony-formation ability of CRC cells. LEM-14 exhibits enhanced anti-tumor efficacy in Balb/c nude mice bearing LoVo cell xenografts when combined with ionizing radiation. LEM-14 has the potential for the research of multiple myeloma and colorectal cancer[1][2][3].
IC50 & Target:NSD2[1]
In Vitro:LEM-14 (15-30 μM, 48 h) combined with ionizing radiation (IR) to treat colorectal cancer (CRC) cells, enhances the apoptosis rate and reduces the colony-formation ability of CRC cells (HCT116 and LoVo)[3].
In Vivo:LEM-14 (5 mg/kg, i.p., 2 consecutive days injection + 2 days interval, 28 days) exhibits enhanced anti-tumor efficacy in Balb/c nude mice bearing LoVo cell xenografts when combined with ionizing radiation[3].
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