MAP4K4-IN-3
CAS No. : 1811510-58-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $90 | In-stock |
| 25mg | $190 | In-stock |
| 50mg | $300 | In-stock |
| 100mg | $480 | In-stock |
| 200mg | $690 | In-stock |
| 500mg | $1050 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-125012 |
| M.Wt: | 297.74 |
| Formula: | C15H12ClN5 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C) |
MAP4K4-IN-3 (Compound 17) is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. Antidiabetic agent[1]. IC50 & Target: IC50: 14.9 nM (MAP4K4)[1] In Vitro: MAP4K4, a serine/threonine protein kinase may be a viable target for antidiabetic agents[1]. In Vivo: Oral dosing in telemetered rats for 5 days with MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) results in a number of adverse effects. Substantial weight losses (7%) and body temperature increases (0.4°C) relative to controls are observed over the course of the study. For cardiovascular end points, maximal heart rate increases of 25 bpm, relative to controls, are induced by treatment with MAP4K4-IN-3[2].
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