GGTI-286 (hydrochloride)
CAS No. : 181141-66-2
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| Cat. No. : | HY-117935 |
| M.Wt: | 466.04 |
| Formula: | C23H32ClN3O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
GGTI-286 hydrochloride, a potent GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 hydrochloride selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s =2 and >30 μM, respectively). GGTI-286 hydrochloride also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM[1][2]. IC50 & Target: IC50: 2 μM (Geranylgeranylation of Rap1A) in NIH3T3 cells[1]
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