4,5-Dimethoxycanthin-6-one
CAS No. : 18110-87-7
| Size | Price | Stock |
|---|---|---|
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| 10mg | $380 | In-stock |
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| Cat. No. : | HY-N1882 |
| M.Wt: | 280.28 |
| Formula: | C16H12N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic) |
4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae)[1][2].
IC50 & Target: IC50: 1.7 μM (CYP1A2)[2].
Ki: 2.6 μM (CYP1A2)[2]
In Vitro: 4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM[2].
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