3,6-Diaminoacridine (hemisulfate)

3,6-Diaminoacridine hemisulfate is a multifunctional acridine compound. 3,6-Diaminoacridine hemisulfate is an acridine dye and also a DNA inserter. 3,6-Diaminoacridine hemisulfate is a potent broad-spectrum antibacterial agent. Its mechanism is to insert into bacterial DNA, interfering with replication and transcription, leading to bacterial lysis. 3,6-Diaminoacridine hemisulfate is a K_ir3.2 potassium channel blocker and can be used to study the neurological phenotype of Down syndrome. 3,6-Diaminoacridine hemisulfate can penetrate the stratum corneum of the skin and accumulate in the cell nucleus. Long-term exposure may induce skin cancer or other malignant tumors^[1][2][3]. In Vitro:3,6-Diaminoacridine (0.1-10 μM, 24 hours) hemisulfate specifically inhibits the growth of yeast strains expressing Kir3.2 mutants, but has no effect on the growth of the control strains^[2]. In Vivo:3,6-diaminoacridine (20 mg/kg; intravenous injection; single administration) hemisulfate decreases rapidly from the blood within 5 minutes after administration, followed by a slower decline rate^[3].