VU0650786
CAS No. : 1809085-30-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $300 | In-stock |
| 10mg | $420 | In-stock |
| 25mg | $850 | In-stock |
| 50mg | $1400 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-108710 |
| M.Wt: | 387.80 |
| Formula: | C18H15ClFN5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1].
IC50 & Target: IC50: 392 nM (mGlu3)[1].
In Vivo: VU0650786 (VU786) (i.p., 30 mg/kg) increases the proportion of c-Fos-positive cells by approximately 4-fold, enhances synaptic strength in cone cell subpopulations, weakens thalamocortical long-term depression (LTD), and reduces passive coping in acute models of antidepressant-like activity in inducible cFos-EGFP mice[2].
The pharmacokinetic parameters of VU0650786 (compound 106) in rats[1].
| Parameters | IV (0.2 mg/kg) |
| t1/2 (min) | 42 |
| CL plasma (mL/min/kg) | 37 |
| VSS (L/kg) | 1.6 |
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