P62-mediated mitophagy inducer
CAS No. : 1809031-84-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $260 | In-stock |
| 50mg | $420 | In-stock |
| 100mg | $670 | In-stock |
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| Cat. No. : | HY-115576 |
| M.Wt: | 392.15 |
| Formula: | C14H9IN4O2 |
| Purity: | >98 % |
| Solubility: |
P62-mediated mitophagy inducer (PMI) is a P62-mediated mitophagy activator. P62-mediated mitophagy inducer activates mitochondrial autophagy without recruitment of Parkin or collapse of the mitochondrial membrane potential and remains active in cells lacking a fully functional PINK1/Parkin pathway. P62-mediated mitophagy inducer serves as a pharmacological tool to study the molecular mechanisms of mitosis, avoiding toxicity and some of the non-specific effects associated with the sudden dissipation of mitochondria lacking membrane potential[1].
IC50 & Target:mitophagy[1].
In Vitro:P62-mediated mitophagy inducer (10 μM; 0, 1, 3, 6, 24 h) stabilizes Nrf2 and (10 μM; 9 h) upregulates P62 expression activating mitophagy[1].
P62-mediated mitophagy (10 μM; 24 h) acts downstream of the PINK1/Parkin signaling pathway in MEFs[1].
P62-mediated mitophagy inducer positively affects mitochondrial poly-ubiquitination and coupling[1].
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