(2S,3R)-LP99
CAS No. : 1808948-28-8
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| Cat. No. : | HY-116227 |
| M.Wt: | 516.05 |
| Formula: | C26H30ClN3O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1]. In Vitro: (2S,3R)-LP99 (compound 60) (0-100 µM) inhibits the expression of IL6 in LPS-stimulated (100 ng/mL) THP-1 cells[1].
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