CHMFL-ABL-053
CAS No. : 1808287-83-3
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| Cat. No. : | HY-101268 |
| M.Wt: | 549.55 |
| Formula: | C28H26F3N7O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CHMFL-ABL-053 (Compound 18a) is a potent, selective, and orally available BCR-ABL, SRC and p38 kinase inhibitor with IC50 values of 70, 90 and 62 nM against ABL1, SRC and p38, respectively[1]. In Vitro: CHMFL-ABL-053 (Compound 18a) inhibits the proliferation of CML cell lines with GI50 of 14, 25 and 16 nM against K562, KU812 and MEG-01, respectively[1]. In Vivo: CHMFL-ABL-053 (Compound 18a) (50 mg/kg/day) almost completely suppresses tumor progression in the K562 cells inoculated xenograft mouse model[1].
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- Cat. No.:
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