Corin
CAS No. : 1808113-09-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $220 | In-stock |
| 5mg | $550 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1280 | In-stock |
| 50mg | $1720 | In-stock |
| 100mg | $2300 | In-stock |
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| Cat. No. : | HY-111048 |
| M.Wt: | 428.53 |
| Formula: | C26H28N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1. IC50 & Target: IC50: 147 nM (HDAC1), Ki(inact): 110 nM (LSD1)[1]. In Vitro: Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC50 95 nM vs. MS-275 EC50 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM)[1].
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