PF-06471553
CAS No. : 1808094-07-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $480 | In-stock |
| 10mg | $740 | In-stock |
| 25mg | $1400 | In-stock |
| 50mg | $2300 | In-stock |
| 100mg | $3300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-108339 |
| M.Wt: | 467.54 |
| Formula: | C23H25N5O4S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 150 mg/mL |
PF-06471553 is a potent, selective and orally available monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM. IC50 & Target: IC50: 92 nM (MGAT3)[1] In Vitro: PF-06471553 (6f) is a potent and selective monoacylglycerol acyltransferase 3 (MGAT3) inhibitor, with an IC50 of 92 nM, and shows >160 fold in vitro selectivity for MGAT3 over DGAT1 (IC50, >50 μM), DGAT2 (IC50, >100 μM), MGAT1 (IC50, 14.9 μM), and MGAT2 (IC50, 19.8 μM). PF-06471553 exhibits inhibitory activity against MGAT3 in HEK-293 cells with an IC50 of 205 nM (pIC50, 6.69)[1]. In Vivo: PF-06471553 (200 mg/kg, p.o.) in addition with (DGAT1 and DGAT2) inhibitors shows additional inhibition of glycerol-d5 incorporated triolein in hMGAT3 mice, and with no effect on WT mice[1].
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Inquiry Information- Product Name:
- PF-06471553
- Cat. No.:
- HY-108339
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