Clazosentan
CAS No. : 180384-56-9
(Synonyms: Ro 61-1790; VML 588; AXV-034343)
| Size | Price | Stock |
|---|---|---|
| 1mg | $85 | In-stock |
| 5mg | $220 | In-stock |
| 10mg | $347 | In-stock |
| 25mg | $762 | In-stock |
| 50mg | $1230 | In-stock |
| 100mg | $1590 | In-stock |
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| Cat. No. : | HY-17352 |
| M.Wt: | 577.57 |
| Formula: | C25H23N9O6S |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5]. In Vitro:Clazosentan (0.1 μM) inhibits the ETA receptor in cerebral arteries[3]. Clazosentan is a substrate of the organic anion-transporting polypeptide (OATP) 1B1/1B3[5]. In Vivo:Clazosentan (10 μM, 0.05?mL/kg, intracisternal injection) inhibits the contractile responses to ET-1 in rats[2]. Clazosentan (10 mg/kg, s.c.) inhibits IL-33-induced hypernociception in mice[4].
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