S-22153
CAS No. : 180304-07-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $680 | In-stock |
| 25mg | $1320 | In-stock |
| 50mg | $2080 | In-stock |
| 100mg | $3600 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-114962 |
| M.Wt: | 247.36 |
| Formula: | C14H17NOS |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
S-22153 is a potent melatonin receptor antagonist with EC50 values of 19 nM, 4.6 nM for hMT1 and hMT2 melatonin receptor, respectively. S-22153 has Ki values of 8.6 nM (CHO cells) and 16.3 nM (HEK cells) for hMT1, and 6.0 nM (CHO cells) and 8.2 nM (HEK cells) for hMT2. S-22153 is a specific ligand of MT1 and MT2 melatonin receptors subtypes[1][2]. IC50 & Target: EC50: 19 nM (MT1 receptor), 4.6 nM (MT2 receptor)[2] In Vivo: S-22153 sets the temperature and activity periods to approximately 24 hr and increase the circadian amplitude of both rhythms in mice, which exposed to continuous light[1] .
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