Vimirogant
CAS No. : 1802706-04-2
(Synonyms: VTP-43742)
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| Cat. No. : | HY-103637 |
| M.Wt: | 552.65 |
| Formula: | C27H35F3N4O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Vimirogant (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant has the potential for autoimmune disorders research[1][2]. IC50 & Target: Ki: <100 nM (RORγ)[1] In Vitro: Vimirogant inhibits the secretion of IL-17A from activated hPBMCs (IC50=18 nM) and human whole blood (IC50=192 nM)[1]. In Vivo: In the MOG35-55/CFA immunized mouse EAE model, Vimirogant (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord[1].
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