BPTQ
CAS No. : 1802665-43-5
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| Cat. No. : | HY-124122 |
| M.Wt: | 308.40 |
| Formula: | C17H16N4S |
| Purity: | >98 % |
| Solubility: |
BPTQ is a potent inhibitor against VEGFR1 and CHK2 with IC50 values of 0.54 and 1.70 µmol/L, respectively. BPTQ is also an intercalator of DNA with anticancer activities. BPTQ inhibits the proliferation of HL-60 cells by arresting cells at S and G2/M phase with an IC50 value of 12 µmol/L. BPTQ also activates the mitochondria-mediated Apoptosis pathway by a decrease in mitochondrial membrane potential, increase in the Bax:Bcl-2 ratio and activation of caspases[1][2].
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