ONO-8590580
CAS No. : 1802661-73-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $220 | In-stock |
| 25mg | $490 | In-stock |
| 50mg | $790 | In-stock |
| 100mg | $1250 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-112788 |
| M.Wt: | 376.43 |
| Formula: | C21H21FN6 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
ONO-8590580 is a GABAA α5 negative allosteric modulator. IC50 & Target: GABAA α5[1]. In Vivo: The effect of ONO-8590580 on the MK-801/scopolamine-induced cognitive deficit in the 8-arm radial maze test is investigated. Doses of MK-801 and scopolamine for this test are 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.) respectively. ONO-8590580 (20 mg/kg, p.o.) significantly decreases the number of errors and total latency compared to the control. The present study in which ONO-8590580 but not donepezil significantly decreases the number of errors may suggest that ONO-8590580 could be more potent for the treatment of AD patients. The data showing that ONO-8590580 has not anxiogenic-like or proconvulsant effects are in agreement with the behavioral phenotype of α5-/- mice[1].
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