NY0123
CAS No. : 1801911-70-5
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| Cat. No. : | HY-123795 |
| M.Wt: | 399.66 |
| Formula: | C16H13Cl3N4O2 |
| Purity: | >98 % |
| Solubility: |
NY0123 is a EPAC1 inhibitor. NY0123 significantly inhibits the expression of EPAC1, phosphorylated AKT, phosphorylated ERK1/2 and phosphorylated VEGFR2. NY0123 inhibits angiogenesis and tumor growth of triple-negative breast cancer. NY0123 is applicable to relevant research on triple-negative breast cancer[1].
In Vivo:NY0123 (10 mg/kg; i.p.; every two days; 14 days) significantly suppresses triple-negative breast cancer tumor growth, angiogenesis, and cell proliferation in BALB/c mice with greater efficacy than ESI-09 and no observed organ toxicity[1].
NY0123 (25-100 μM; topical application to CAM; single dose; 48-hour incubation) significantly suppresses angiogenesis in Gallus gallus domesticus embryo CAM models with greater efficacy than ESI-09[1].
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