BMS-986169
CAS No. : 1801151-08-5
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| Cat. No. : | HY-119886 |
| M.Wt: | 382.47 |
| Formula: | C23H27FN2O2 |
| Purity: | >98 % |
| Solubility: |
BMS-986169 is an inhibitor of the glutamate N-methyl-D-aspartate 2B receptor (GluN2B). BMS-986169 has a high binding affinity for the allosteric regulatory site of the GluN2B subunit, with a Ki value of 4.03-6.3 nM. BMS-986169 can inhibit the function of GluN2B receptors in Xenopus oocytes, with an IC50 value of 24.1 nM. BMS-986169 can also inhibit the activity of the hERG channel, with an IC50 value of 28.4 μM. BMS-986169 can be used in research on treatment-resistant depression[1].
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