ATP-polyamine-biotin
CAS No. : 1800401-93-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $540 | In-stock |
| 2mg | $860 | In-stock |
| 5mg | $1680 | In-stock |
| 10mg | $2355 | In-stock |
| 25mg | $3800 | In-stock |
| 50mg | $5200 | In-stock |
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| Cat. No. : | HY-D0183 |
| M.Wt: | 945.85 |
| Formula: | C32H58N11O14P3S |
| Purity: | >98 % |
| Solubility: | H2O : 6 mg/mL (ultrasonic;warming) |
ATP-polyamine-biotin, the first cell-permeable ATP analogue, is an efficient kinase cosubstrate. ATP-polyamine-biotin promotes biotin labeling of kinase substrates in live cells[1]. In Vitro: ATP-polyamine-biotin (APB) is incubated with PKA kinase and full-length protein substrate, myelin basic protein (MBP). Biotinylation was observed only in presence of kinase. In addition, MBP biotinylation was lost in the absence of ATP-polyamine-biotin, in presence of the kinase inhibitor staursporine or upon incubation with acid due to cleavage of phosphoramidate bond. Biotinylated kemptide product is observed only in the presence of APB cosubstrate[1].
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