BMS-986158
CAS No. : 1800340-40-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $99 | In-stock |
| 5mg | $330 | In-stock |
| 10mg | $490 | In-stock |
| 25mg | $940 | In-stock |
| 50mg | $1290 | In-stock |
| 100mg | $1750 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101567 |
| M.Wt: | 495.62 |
| Formula: | C30H33N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
BMS-986158 is a potent BET inhibitor with IC50s of 6.6 and 5 nM in NCI-H211 small cell lung cancer (SCLC) cells and MDA-MB231 triple negative breast cancer (TNBC) cells, respectively[1]. IC50 & Target: IC50: 6.6 nM (BET, in NCI-H211 SCLC cells), 5 nM (in MDA-MB231 TNBC) cells)[1] In Vitro: BMS-986158 is an inhibitor of the bromodomain (BRD) and extra-terminal domain (BET) family of proteins, with potential antineoplastic activity. Upon administration, the BET inhibitor BMS-986158 binds to the acetyl-lysine binding site in the BRD of BET proteins, thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and prevents the expression of certain growth-promoting genes, resulting in an inhibition of tumor cell growth[2].
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