TP-020
CAS No. : 1800025-30-2
(Synonyms: MGAT2-IN-1)
| Size | Price | Stock |
|---|---|---|
| 1mg | $180 | In-stock |
| 5mg | $540 | In-stock |
| 10mg | $900 | In-stock |
| 25mg | $1800 | In-stock |
| 50mg | $2640 | In-stock |
| 100mg | $4200 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-101857 |
| M.Wt: | 654.01 |
| Formula: | C27H21ClF5N7O3S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
TP-020 (MGAT2-IN-1) is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively. IC50 & Target:IC50: 7.8 nM (Human MGAT2), 2.4 nM (Mouse MGAT2)[1] In Vivo:TP-020 (3, 10 mg/kg, p.o.) dose-dependently suppresses plasma TG elevation, and plasma CM/TG AUC in mice. TP-020 does not decrease MG absorption but inhibits MGAT2-dependent TG/DG resynthesis. In the lipid utilization analysis, TP-020 significantly increases free fatty acid (FFA) and acylcarnitine levels. TP-020 (30 mg/kg) also significantly reduces food intake dose dependently, suppresses BW gains. TP-020 shows anti-diabetic effects in mice[1].
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