1400W
CAS No. : 180001-34-7
(Synonyms: W1400)
| Size | Price | Stock |
|---|---|---|
| 5mg | $85 | In-stock |
| 10mg | $135 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $375 | Get quote |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-18730 |
| M.Wt: | 177.25 |
| Formula: | C10H15N3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase (iNOS) inhibitor, with a Kd value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation[1][2].
IC50 & Target:Ki: 2 µM (nNOS), 50 µM (eNOS)[1]
In Vitro:1400W (60 μM, 1 h) reduces NO, 3-NT and MDA production in primary adult microglia, and prevents neuronal cell apoptosis in cerebral cortex[2].
In Vivo:1400W (0.1-10 mg/kg, s.c., once time) inhibits the leakage of rats ileum, with an EC50 of 0.16 mg/kg[1].
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