PF-6683324
CAS No. : 1799788-94-5
(Synonyms: Trk-IN-4)
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $390 | In-stock |
| 50mg | $660 | In-stock |
| 100mg | $1150 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112436 |
| M.Wt: | 521.46 |
| Formula: | C24H23F4N5O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
PF-6683324 (Trk-IN-4) is a potent pan-Trk inhibitor in cell-based assays with IC50s of 1.9 nM, 2.6 nM and 1.1 nM for TrkA, TrkB and TrkC, respectively[1]. Anti-hyperalgesic effect[1]. In Vitro: PF-6683324 (Trk-IN-4) (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC50>5 μM)[1].
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