MIK665
CAS No. : 1799631-75-6
(Synonyms: S-64315)
| Size | Price | Stock |
|---|---|---|
| 1mg | $166 | In-stock |
| 5mg | $350 | In-stock |
| 10mg | $550 | In-stock |
| 25mg | $1020 | In-stock |
| 50mg | $1650 | In-stock |
| 100mg | $2300 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112218 |
| M.Wt: | 875.41 |
| Formula: | C47H44ClFN6O6S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 125 mg/mL |
MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor[1]. MIK665 has an IC50 of 1.81 nM for MCL1[2].
IC50 & Target: IC50: 1.81 nM (Mcl-1)[1]
In Vitro: MIK665 (S-64315) has similar synergistic effects as S63845, when combined with ABT-199. The combination S64315 (0.156-10 μM) and ABT-199 (625 nM) has similar efficacy in reducing the cell viability of representative melanoma lines (MB2141, MB3616, MB3961, MB4667, A375, and 1205Lu cells)[1].
MIK665 is extracted from patent WO2016207225A1, compound Preparation 13, and inhibits H929 cell with an IC50 of 250 nM[2].
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