Centrinone-B
CAS No. : 1798871-31-4
(Synonyms: LCR-323)
| Size | Price | Stock |
|---|---|---|
| 5mg | $144 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $850 | In-stock |
| 100mg | $1360 | In-stock |
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| Cat. No. : | HY-18683 |
| M.Wt: | 631.67 |
| Formula: | C27H27F2N7O5S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. IC50 & Target: Ki: 0.59 nM (PLK4), 1239 nM (Aurora A), 5597.14 nM (Aurora B)[1] In Vitro: Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. Centrinone-B slightly binds to Aurora A and Aurora B, with Kis of 1239 nM and 5597.14 nM. Centrinone-B (LCR-323) exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes[1]. Centrinone-B (LCR-323) (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Inhibition of PLK4 by Centrinone-B (LCR-323) also induces apoptosis in human melanoma cell lines[2].
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