PF-04822163
CAS No. : 1798334-07-2
Price and Availability of
CAS No. : 1798334-07-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $646 | Get quote |
| 5mg | $1548 | Get quote |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-120741 |
| M.Wt: | 340.80 |
| Formula: | C19H17ClN2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Introduction of
1798334-07-2
:
PF-04822163 is an orally active, selective, and blood-brain barrier permeable PDE1 inhibitor with IC50 values of 2 nM, 2.4 nM, and 7 nM for PDE1A, PDE1B, and PDE1C respectively. PF-04822163 can be used in the research of attention deficit hyperactivity disorder or Parkinson's disease[1].
In Vivo:PF-04822163 (10 mg/kg; p.o.; single dose) achieved a Tmax of 274 ng/mL in rat plasma at 0.5 h, with a terminal half-life of 5.5 h, and showed blood-brain barrier permeability[1].
Pharmacokinetic parameters in rat[1]
| species | route | dose | Tmax(h) | t1/2(h) | fu | B/P | CSF/Pu |
| rat | p.o. | 10 mg/kg | 0.5 | - | 0.028 | 3.4 | 1.7 |