Tanomastat
CAS No. : 179545-77-8
(Synonyms: BAY 12-9566)
| Size | Price | Stock |
|---|---|---|
| 500μg | $86 | Get quote |
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| Cat. No. : | HY-12168 |
| M.Wt: | 410.91 |
| Formula: | C23H19ClO3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The Ki values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models[1][2][3].
In Vitro: Tanomastat (BAY 12-9566) (1-10000 nM; 6 hours) prevents matrix invasion by endothelial cells in a concentration-dependent manner (IC50=840 nM), without affecting cell proliferation[2].
Tanomastat (BAY 12-9566) (1-00 µM; 5 days) inhibits tubule formation completely at 15-100 µM[3].
In Vivo: Tanomastat (BAY 12-9566) (100 mg/kg; p.o.; daily for a 7-week period) inhibits local tumor regrowth without causing any toxic effect, and inhibits the number and volume of lung metastases[3].
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