Bortezomib (Standard)
CAS No. : 179324-69-7
(Synonyms: PS-341 (Standard); LDP-341 (Standard); NSC 681239 (Standard))
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| Cat. No. : | HY-10227R |
| M.Wt: | 384.24 |
| Formula: | C19H25BN4O4 |
| Purity: | >98 % |
| Solubility: |
Bortezomib (Standard) is the analytical standard of Bortezomib. This product is intended for research and analytical applications. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Bortezomib can be used for the study of multiple myeloma (MM)[1][2]. Bortezomib effectively inhibits TREM2 expression in tumor-associated macrophages (TAMs)[7].
IC50 & Target:Ki: 0.6 nM (20S proteasome)[1]
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