HEC72702
CAS No. : 1793063-59-8
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| Cat. No. : | HY-123767 |
| M.Wt: | 581.45 |
| Formula: | C24H26BrFN4O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
HEC72702 is a potent and orally active hepatitis B virus capsid inhibitor with an EC50 values of 0.039 µM. HEC72702 dose-dependently reduced HBV DNA in both the plasma and livers[1].
IC50 & Target:EC50: 0.039 µM (hepatitis B virus capsid)[1]
In Vivo:HEC72702 (50, 100 mg/kg; p.o.; daily for 7 days) dose-dependently reduces HBV DNA in both the plasma and livers copies[1].
Pharmacokinetic Parameters of HEC72702 in Male Sprague-Dawley rats[1].
| dose (mg/kg) | iv (2) | po (5) |
| AUC(0-24 h) (h*ng/mL) | 4110 | 4900 |
| CL (mL/min/kg) | 8.11 | |
| VSS (L/kg) | 0.41 | |
| F % | 47.7 |
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- Cat. No.:
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