SB-237376 (free base)
CAS No. : 179258-59-4
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|---|---|---|
| 1mg | $358 | Get quote |
| 5mg | $894 | Get quote |
| 10mg | $1306 | Get quote |
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| Cat. No. : | HY-108163 |
| M.Wt: | 387.43 |
| Formula: | C20H25N3O5 |
| Purity: | >98 % |
| Solubility: |
SB-237376 (free base) is a potassium and calcium channel blocker. SB-237376 (free base) can inhibit the rapidly activating delayed rectifier potassium current I(Kr) (IC50 is 0.42 μM), and at high concentrations, it blocks the L-type calcium current I(Ca,L). In the rabbit ventricular model, SB-237376 (free base) can induce early afterdepolarizations (EADs) at a concentration of 3 µM. Compared to other IKr inhibitors such as dl-sotalol, SB-237376 has a lower proarrhythmic risk. SB-237376 (free base) holds potential for research in the field of arrhythmia-related diseases[1].
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