3-Hydroxy Midostaurin
CAS No. : 179237-49-1
(Synonyms: CGP52421)
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| Cat. No. : | HY-108263 |
| M.Wt: | 586.64 |
| Formula: | C35H30N4O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1]. IC50 & Target: IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)[1] In Vitro: CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM[1].
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- 3-Hydroxy Midostaurin
- Cat. No.:
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