Altinicline
CAS No. : 179120-92-4
(Synonyms: SIB-1508Y (free base))
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| Cat. No. : | HY-14318 |
| M.Wt: | 186.26 |
| Formula: | C12H14N2 |
| Purity: | >98 % |
| Solubility: |
Altinicline (SIB-1508Y free base) is a selective α4β2 nicotinic acetylcholine receptor (nAChR) agonist, with no activity against α7 or α1β1γδ nAChRs and only extremely low activity against α3β4 nAChRs. Altinicline reverses escape deficits and increases avoidance responses. Altinicline is applicable to research related to depression[1]. In Vivo:Altinicline (SIB-1508Y) (0.375-1.5 mg/kg/day; s.c.; subchronic: 5 consecutive days, chronic: 4 weeks prior plus 5 days post-testing start) produces significant, long-lasting reversal of inescapable shock-induced escape failures in the learned helplessness rat model of depression, with additional enhancement of avoidance learning, via a nicotinic acetylcholine receptor-mediated mechanism[1].
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