Myricitrin

Myricitrin, a naturally occurring flavonoid, is an orally active nitric oxide (NO) and PKC inhibitor. Myricitrin has central nervous system activity, including anxiolytic-like action. Myricitrin possesses antioxidant, anti-inflammatory, antifibrotic and anti-malarial effects^{[1][2][3][4][5]}. In Vitro:Myricitrin has strong antioxidant activity as radical scavenger and metal-ion chelator. Myricitrin has been reported to inhibit the aldose reductase activity and the oxidation of low-density lipoprotein, and has anti-malarial effect^[1].
Myricitrin exhibits a strong scavenging activity against DPPH and NO radicals, as well as H₂O₂ (IC₅₀ = 1.31 μg/mL, 21.54 μg/mL and 28.46 μg/mL, respectively)^[2].
Raw264.7 cells are pre-treated with Myricitrin (0.2-1 mM) for 2 h and stimulates with LPS (HY-D1056) at a concentration of 100 ng/mL for 4 h. Myricitrin inhibits TNFα production and enhances RANTES (regulated on activation normal T-cell expressed and secreted) production in LPS-stimulated Raw264.7 cells. It should be noted that the inhibitory effect of Myricitrin is not observed when Myricitrin was added either simultaneously or after LPS stimulation^[3].
Myricitrin shows proliferation inhibition of Plasmodium falciparum, with IC₅₀ value of 5.4 µg/mL^[4]. In Vivo:Myricitrin (10-100 mg/kg; oral gavage; once daily; for two consecutive days) exhibits antioxidant, anti-inflammatory and antifibrotic activity in Carbon tetrachloride (CCl4) (HY-Y0298)-intoxicated mice^[2].
Myricitrin (5-30 mg/kg; i.p.; once) dose-dependently blocks the stereotypy and climbing induced by Apomorphine (HY-12723) at doses that does not induce catalepsy^[5].